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An increase in metHb levels and in its linkage to the RBC membrane, accompanied by ROS formation, was also found in stored RBCs for blood transfusion [30] and in exogenous H 2 O 2 -induced OS upon healthy erythrocytes [31, 32]

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Subsequent gene ontology (GO) enrichment analysis revealed pathways related to immunity and barrier function that were enriched in the skin of butyrate-treated mice