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In Cell Injury and Protection in the Gastrointestinal Tract: From Basic Sciences to Clinical Perspectives

Published material on the related Pliva development codes PL-10, PLD-116, and PL-14736 has concentrated on preclinical wound, tissue-protection, and gastrointestinal-injury models rather than randomized human efficacy data, and the peer-reviewed record does not contain a confirmatory efficacy readout for the indications most commonly associated with BPC-157 in informal discussion

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For instance, Opc is possessed only by the meningococcus, and Opa proteins have different affinities for CEACAM members, with meningococcal Opa primarily targeting CEACAM1 and gonococcal Opa proteins binding to CEACAM1, CEACAM5, CEACAM6, and CEACAM3 on epithelia, neutrophils, and lymphocytes (Sadarangani et al., 2011