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While Vitamin B12 is a naturally occurring nutrient that is generally considered very safe even in high doses, it is still a medical treatment

References Warburg, O

These results collectively indicate that Sirt1 is indispensable for NNMT-mediated regulation of glucose metabolism, and both NNMT and MNAM have the ability to upregulate Sirt1 expression

Data from the cross-sectional MORGEN study, (the monitoring project on risk factors and health in the Netherlands) in a sample of 6555 adults in the Dutch population, showed that the intake of vitamin C and beta-carotene, but not vitamin E, had a positive effect on lung function, but had no effect on respiratory symptoms

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