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Alzheimers Disease And Cognitive Decline Glutathione has not yet been tested intranasally in people with Alzheimers disease (AD), but observational data show: Lower glutathione levels in the hippocampus and frontal cortex of people with AD and mild cognitive impairment An association between lower brain glutathione and higher amyloid plaque burden in older adults People carrying the ApoE4 gene variant , a major genetic risk factor for AD, appear to have: Higher oxidative stress in brain tissue Lower levels of reduced glutathione compared to noncarriers These findings support the idea that glutathione is closely tied to brain aging and degeneration, though we still lack clinical trials testing intranasal glutathione in AD or ApoE4 carriers