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NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis

The APC was funded by Arturo Prat Universidad Arturo University project Apoyo Para Financiamiento De rticulos En Revistas Cientficas De Acceso Abierto, Article Processing Charges (APC)-2026

While Cerebrolysin is a complex mixture of hundreds of peptides and amino acids from porcine brain tissue, P21 is a single defined compound targeting one specific pathway, LIF inhibition leading to BDNF upregulation

GLS1 has two splice variants: KGA (the full-length variant) and GAC (which is missing the C-terminal)

Diseases such as viral hepatitis (hepatitis B and C), nonalcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD), and drug-induced liver injury (DILI) substantially contribute to this burden, posing a major public health challenge (2)