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Olaparib treatment also replenished NAD + levels, enhanced mitochondrial function, and promoted fatty acid oxidation, thereby reversing non-alcoholic fatty liver disease (NAFLD) in mice fed a high-fat, high-sucrose diet 164 (Fig

Serotonin reuptake inhibition: Enhances satiety signals Reduces appetite Improves mood (reduces emotional eating) Stabilizes cravings Similar to SSRIs but different profile Potency ratios: Why triple inhibition powerful: Attacks weight loss from multiple angles Metabolic + appetite + behavioral changes Synergistic effects stronger than single pathway But also multiplies side effect risks Different from GLP-1 single mechanism Compare to semaglutide mechanism and other weight loss approaches

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