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Previous findings demonstrated that p53 is activated in AT of obese and diabetic mice and humans in response to DNA damage, consequently inducing adipocyte senescence and the recruitment of macrophages 23

10.1016/s0140-6736(96)10508-0 Lancet

A roadmap to creating ferroptosis-based medicines

AT1R blockers, such as losartan, have been investigated for their potential to mitigate BBB damage (Huang and Zhang, 2024)

The 2021 Nature Metabolism study showed 5-Amino-1MQ reduced white adipose tissue by 35% in mice without caloric restriction, alongside improved insulin sensitivity