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Notably, the intra-articular delivery of a lentivirus expressing FOXO3 was found to effectively alleviate high-fat diet-induced cartilage degeneration and subchondral bone remodeling

A systemically injected KPV does not obviously arrive at a skin or joint injury through the same targeted, transporter-driven route, so the animal colitis data cannot simply be lifted onto the systemic recovery claims

Epigenetic regulation of Nrf2 Epigenetics modifications including DNA methylation, histone modification, and microRNAs (miRNAs) expressions are involved in Nrf2 regulation (Yu et al., 2010

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[DOI] [PMC free article] [PubMed] [Google Scholar] 53.Kozak M A second look at cellular mRNA sequences said to function as internal ribosome entry sites