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GSTs have been shown to play an important role in insecticide resistance

However, a recently published phase II clinical trial using the iron chelator deferiprone reported that deferiprone was ineffective in newly diagnosed PD patients who had not previously received dopaminergic therapy and even worsened both motor and non-motor symptoms [177]

CusumanoVRossanoFMerendinoRArenaACostaGMancusoGet al

Moreover, an abundance of iron and susceptibility to oxidative stress have resulted in the hypothesis that erythrocytes might undergo ferroptosis, an iron-driven ROS-dependent RCD [78]