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Therefore, in-depth studies on the structureactivity relationship, mechanisms of action, efficacy, toxicology, and clinical application potential of anti-allergic active substances should be carried out to make active substances more attractive drugs

This is also consistent with earlier studies showing that cystine starvation activates GCN2 rather than PERK 47 and the lack of enhanced splicing of the XBP1 mRNA upon erastin treatment 9