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The restitution of redox equilibrium in the face of an oxidative challenge, therefore, requires an adaptive cross-talk between signaling pathways sensing variations in p O 2 and genetically regulated transcription factors [2, 3, 1618, 26, 51]

doi: 10.1016/j.fct.2016.08.011

In fact, some preclinical studies suggest that raising NAD+ levels may have beneficial effects and, in certain contexts, may even help suppress tumor growth.' These findings reinforce that cancer is complex and multifactorial: while NAD+ participates in metabolism that cancer cells use, it does not override the many factors that drive cancer risk