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Relative H 2 O 2 ( c ), acrolein ( d ) and lipid ROS ( e ) levels, and viability analysis ( f ) in the SMS-knockout or APCHA (100 uM) -treated PDLCs and SNU449 cells cultured in dFBS medium, following pre-treatment with vehicle or MJP plus vehicle, or spermidine (10 uM), or spermine (10 uM) for 24 h, followed treatment of RSL3 (1 uM) or erastin (5 uM) for 24 h