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Depending on the peptide, some people notice temporary water retention, headache, flushing, fatigue, or appetite changes

10.3389/fcell.2020.590226 76 ChenY.LiM.WenJ.PanX.DengZ.ChenJ.et al (2022e)

Together, these findings highlight a distinct metabolic signature in ME/CFS, where energy production pathways may fail to respond efficiently to physical exertion, potentially driving exacerbation of symptoms seen in PEM