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Description

-Ketoglutarate dehydrogenase is a therapeutic vulnerability in acute myeloid leukemia [J]

10.3109/03602532.2014.1003649 109 Gonzlez de VegaR

The Met cycle is closely regulated by the folate cycle, in which folic acid is first converted into tetrahydrofolate (THF), then into 5,10-methylene THF and, ultimately, into 5-methyl THF by the enzyme methylenetetrahydrofolate reductase (MTHFR)