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Neuroprotective mechanisms Many studies have shown that the epileptogenic state involves complex molecular pathways in which oxidative stress and mitochondrial dysfunction may exert important roles in neuronal programmed/controlled (apoptosis) or uncontrolled/passive (necrosis) cell death 42

[] Luo Ren had used the methods of soothe the liver, regulate qi and promote urination (), clearing the liver, remove toxins and promote urination (), soothe the liver, transform stasis and unblock collaterals (), nourish the liver and the kidney (), soothe the liver and submerge yang (), and others to treat nephritis, for example, Xiao-Si-Wu-Tang (), which includes Xiao-Chai-Hu-Tang () with the actions of disperse and unblock the sanjiao () and regulate and harmonize qi, Wu-Ling-San () with the actions of urination-promoting and dampness-draining, and Si-Wu-Tang with the action of nourishing and circulating the blood, was used to treat nephrotic syndrome

Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonins neuroprotective activity after focal cerebral ischemia in mice