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Standard interventions include dietary branched-chain amino acid restriction to limit precursor influx, Cbl supplementation in vitamin B12-responsive patients to augment residual MMUT activity, carnitine administration to promote propionylcarnitine excretion, and betaine supplementation to promote Hcy remethylation

Puranam and Attardi, 2001

Cocaine induces intense sympathetic activation through inhibition of norepinephrine reuptake, leading to tachycardia, hypertension, and vasoconstriction