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Yoon YM, Kim HJ, Lee JH, Lee SH (2019) Melatonin enhances mitophagy by upregulating expression of heat shock 70kDa protein 1L in human mesenchymal stem cells under oxidative stress

Chen, N., S

The second generation (20112018) introduced humanized antibodies, cleavable linkers, and engineered conjugation sites, improving DAR consistency (typically ~3-4) and enabling the use of potent microtubule inhibitors like MMAE and DM1