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If after increasing the dosage, unacceptable opioid-related adverse reactions are observed (including an increase in pain after dosage increase), consider reducing the dosage (see WARNINGS)

Zeevalk GD, Bernard LP, Guilford FT

The process is divided into two main steps, where the nanoparticles are first adsorbed on the cell membrane and then internalized through energy-dependent pathways[143, 144]