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This reductive effect on IOP, however, was observed to dwindle after 3090 days of treatment at the 0.25% concentration of apraclonidine

The combined effects of metabolic burden and cellular stress lead to a significant decline in microbial biosynthesis, a phenomenon known as metabolic cliff (Vermelho et al., 2024)

One can say that hes put himself on a better ageing trajectory, but one cannot say that he has reversed or eliminated ageing. What about the other criticisms

Effects of ageing on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxic effects on striatum and brainstem in the rat

That said, in people with a mix of black or brown and white hair, the hair can look whiter after a stressful event