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Nevertheless, regardless of the details of the study design, prioritising the safety of participants should always be the paramount concern in conducting a first-in-human trial

Published research suggests this sustained profile can blunt natural GH pulsatility over time and may reduce the somatotroph cells responsiveness to GHRH stimulation

Notably, GHRH agonists have demonstrated effects in pancreatic -cell proliferation and metabolic function, suggesting their relevance to research into diabetes

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The study monitored for erythema, itching, scarring, atrophy, telangiectasias, and post-inflammatory hyperpigmentation, none of which were observed