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A postmortem study reported reduced neural mRNA expression of the tricarboxylic acid cycle enzyme malate dehydrogenase in BD [53]

Through intricate crosstalk within a signaling network, these pathways collectively enable cellular adaptation to environmental perturbations while preserving homeostasis

In addition to iron deficiency anemia, other medical conditions can cause RLS symptoms - this is called secondary RLS - for example: Chronic kidney disease and kidney failure Peripheral neuropathy Attention deficit hyperactivity disorder (ADHD) Substance use disorders Pregnancy Medication-Related Triggers: How Certain Medications Influence RLS Symptoms Certain medications have been linked to RLS, including antidepressants, antihistamines, anti-nausea medicines, and antipsychotics or neuroleptics

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Bers DM (2013) Membrane receptor neighborhoods: snuggling up to the nucleus