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Even if a fraction of the active ingredient reaches the small intestine intact, its absorption is often severely restricted due to unfavorable molecular size, poor intestinal permeability, and extensive hepatic first-pass metabolism

The role of the microbiome in regulating bone remodeling was shown in germ free mice (in C57BL/6 background) which have increased femoral bone density (both trabecular and cortical) when compared to conventionally raised mice [132]

Furthermore, a possible sparing of GSH has been observed with taurine supplementation [89], suggesting indirect redox-balancing roles

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The slow diffusion of SERF2 in TERRA12 rG4 condensates may be due to strong electrostatic interactions of charged lysine and arginine residues with negatively charged nucleic acid bases, as has been observed for other nucleic acid-binding proteins 90