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Start gentle ROM (Week 1) gentle stretching (Weeks 2-4) progressive low-load strengthening (Weeks 2-4) Progress to resistance under PT supervision (Weeks 4-6) Follow structured protocol rather than self-directed progression Increase intensity/duration by no more than 10-15% per week What Should You Do If Symptoms Return After Activity

After thawing, cells were filtered through EASYstrainer 40 m (Greiner), washed with PBS and cultivated in RPMI-1640 (Gibco) supplemented with 10% fetal bovine serum (FBS-12A, Capricorn Scientific), 200 U/mL penicillin and 200 g/mL streptomycin (Gibco)

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No increase in number of adverse events with increasing renal or hepatic impairment was observed, and no new safety or tolerability findings with cagrilintide were identified with renal or hepatic impairment

* Correspondence: Peina Zhou, [email protected]