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2022;387(22):2045-2055.[DOI] 34

Preserves glycogen stores

This allows for the passage of germs, endotoxins, and other toxic chemicals into the bloodstream, which can induce a systemic inflammatory response and further worsen BBB failure (Gu et al., 2021)

Most patients notice the first changes within two weeks: Pain reduction and decreased inflammation come first, followed by improved range of motion and faster recovery as the protocol progresses

Recently, in 2016, a phase 2 trial (N = 332 LOE1a) showed that daily administration of 1500 mg LC or mecobalamin resulted in significant reductions in neuropathy symptom score and neuropathy disability score in diabetic patients