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One 12-week randomized clinical trial found that subjects receiving 1mg daily lost an average of 2.6kg compared to 0.8kg in the placebo group

Dietary B12 deficiency comes from inadequate intake, common in strict plant-based diets

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"ARA 290, a nonerythropoietic peptide engineered from erythropoietin, improves metabolic control and neuropathic pain in patients with type 2 diabetes." Molecular Medicine , 20, 658-666