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Nature Scientific Reports 2016 comparative study showed GHK-Cu produced no cytotoxicity to human keratinocytes at concentrations up to 5,800 M over 72 hours and did not induce inflammatory biomarkers unlike other copper compounds

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Abstract Steroidal 5-reductase is a system of NADPH dependent enzyme that catalyzes the irreversible conversion of 43-ketosteroid precursor (testosterone) to its corresponding 5-reduced metabolite (dihydrotestosterone)

Gene expression matrices for RNA-sequencing are available in GEO depository