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AMPK activation = increased glucose uptake and fat oxidation Downregulates anabolic processes that consume ATP Promotes mitochondrial biogenesis and cellular resilience MOTSc functions as a mitochondrial-encoded hormone that enhances metabolic flexibility and insulin sensitivity. Lee et al., Cell Metabolism Natural Expression and Peptide Supplementation Your body naturally produces MOTSc, particularly during fasting or exercise

Until this study was reported, it was thought that muscle energy stores were only refilled in muscles at rest

Passive Avoidance Passive avoidance apparatus, (UgoBasile, Italy) composed of light and dark compartments with equal sizes separated by an automatic sliding door, was used

Start 15-minutes prior to training