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Endothelial dysfunction is defined as an impairment in the vascular endothelium, which plays a critical role in maintaining homeostasis, including regulation of normal smooth muscle relaxation

Furthermore, MT helps reduce the production of free radicals in injured tissues, enhances antioxidant capacity, alleviates local inflammatory responses, and prevents neuronal apoptosis

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Various antioxidants of natural and synthetic origin have been found to ameliorate oxidative stress in several models of AD