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on the other, it can intensify oxidative stress by altering metabolic pathways (121)

If these peptides are so safe and effective, why aren't they licensed medicines

[DOI] [PubMed] [Google Scholar] Tach Y, Kolve E, Kauffman G

Rusce, L., et al., Alpha lipoic acid administration improved both peripheral sensitivity to insulin and liver clearance of insulin reducing potential risk of diabetes and nonalcoholic fatty liver disease in overweight/obese PCOS patients

Tricyclic antidepressants including imipramine and amitriptyline are a mainstay of treatment for a variety of chronic pain states, although not FDA-approved for this indication (Tauben & Stacey, 2021)