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The integration of gene therapy, targeted delivery vehicles, and immune-based modulation offers a sophisticated framework to counteract neuronal loss and functional decline in neurodegenerative disorders

HIV-1 proteins, including Tat, Nef, Vpr, protease, and gp120, modulate ROS-generating systems and induce oxidative stress, thereby promoting the expression of viral genes and proinflammatory lymphokines 114,115,116

Endocrine 48(3):756775

Lower SNCA transcripts might be a possible predictor of cognitive decline, and low SNCA transcripts were linked to early PD

Nevertheless, the lack of conclusive results about effectiveness of supplements on CVD, make more research in this field necessary