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It is well known that chemotherapeutic drugs can also arise from natural sources, nearly representing half of the anticancer agents according to Newman and Cragg [96]

As a critical biological component of the upper respiratory tract (URT) mucosal barrier, URT microbiota plays a fundamental role in maintaining local immune homeostasis and reinforcing barrier defenses against environmental pathogens 95,96

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In turn, reduced inflammation may lead to a lower risk of various life-threatening diseases

During its transport to the colon, it is converted into urobilinogen by the bacterial enzyme bilirubin reductase