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Both injections and oral supplements are generally safe, but very high doses of B12 can cause side effects in rare cases, such as mild digestive issues or headaches

It was like having a cross between a cold and a sinus headache

Graphical Abstract Similar content being viewed by others 1 Introduction Globally, the prevalence of ulcerative colitis (UC) has seen a significant rise, particularly in Northern Europe and North America, with two distinct age peaksone between 30 to 40 years and the other occurring in the 5th to 8th decades of life

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The unknown rate constants for R 1 , R 2 , R 3 , R 4 and R 5 for the respective models were fitted using the LSQNONLIN function in MATLAB, a non-linear least squares solver