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However, it is important to realize that an important number of the patients may benefit from the medication, that hepatic, renal, cardiac or neurological deterioration and sudden unexpected death could be prevented, that the life span of erythrocytes is increased [57] and the quality of life in a variety of chronic diseases is improved (e.g

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1 While traditionally studied in isolation, recent advances reveal extensive crosstalk between these pathways, which coordinate protein turnover, stress responses, and quality control under physiological and pathological conditions

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Porrino, L