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By enhancing T-cell infiltration, LDHA inhibitors worked in concert with IDH inhibitors (58)

These data indicate that NO has a substantial impact on the remodeling of glucose oxidation through the TCA cycle in stimulated macrophages (Fig

Natural polyphenols like castalagin (145) and cranberry proanthocyanidins (146) act as prebiotics, reshaping gut microbiota to alter BA profiles (e.g., increasing taurine-conjugated BAs or reducing local BA accumulation, respectively) and exert anti-tumor effects or enhance ICI responsiveness

Therapeutic targeting of the COX/PGE2 axis in CC has been reviewed (129)

First the CAR T-cell-therapy-associated Toxicity (CARTOX) Working Group comprising investigators and representatives from multiple institutions, published consensus guidelines for management of CAR-T-related toxicities including CRS []