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Elevated ROS levels lead to endothelial dysfunction, which is a precursor to atherosclerosis

10.1016/j.yexcr.2016.01.006 302 ZhangL.SuS.ZhuY.GuoJ.GuoS.QianD.et al (2019a)

Its telomerase activation properties have attracted attention in the realm of aging-related research, as telomeres are implicated in cellular aging and proliferation [3]

J Cell Biochem 116:17971805 Boroumand S, Hosseini S, Pashandi Z, Faridi-Majidi R, Salehi M (2019) Curcumin-loaded nanofibers for targeting endometriosis in the peritoneum of a mouse model

Given that glutaryllipoyl adducts form under conditions of glutarate excess on another TCA cycle ketoacid dehydrogenase, the PDHc 9 , we hypothesized that the major role of ABHD11 may be to reverse lipoyl glutarylation, maintaining TCA cycle integrity (Fig