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While no direct clinical trials provide data on optimal human dosing of 6-gingerol for SLE, ginger extracts are generally regarded as safe, with human doses up to 2 grams daily (approximately 25 mg/kg for a 70 kg adult) showing good tolerability in other contexts (219)

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Since protein synthesis is a key function regulated by mTORC1, several approaches to understand the role of mTORC1 in aging have focused on the known translation-related effectors downstream of mTORC1 (Figure 4)

Moreover, injection of creatine pyruvate affected the expression level of gluconeogenesis and glycogenesis enzymes in the liver during the late embryonic phase and early post-hatch indicating that in ovo delivery of creatine pyruvate may increase energy reserves in the liver in broiler chickens early post-hatch (124)