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It also stimulates several antioxidative enzymes such as glutathione peroxidase, glutathione reductase, SOD, and boosts the synthesis of GSH .The antioxidant properties of melatonin prevent acute liver injury induced by CCl4, acetaminophen, ischemia-reperfusion, bile duct ligation, pancreatitis nephrotoxicity and neuronal degeneration [47-56]