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doi: 10.3389/fncel.2020.00163, 76 KhlerS.SchmidtH.FlleP.HirrlingerJ.WinklerU

In a year-and-a-half, the condition of the patient deteriorated from mild stiffness of the joints and tightness of the skin, to complete immobilization, with loss of the use of her extremities and loss of flexible facial characteristics

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