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WRN as a Novel Target of Synthetic Lethality: Current Advances and Future Perspectives. Journal of Medicinal Chemistry 68: 1321813245

Tesofensine is a highly effective appetite suppressant that reduces cravings and overall food intake by acting on neurotransmitters that regulate hunger

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Systemic manifestations may include arthritis, interstitial lung disease (ILD), renal and nervous system involvement, and an increased risk of lymphoma (202)