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Description

(2) Plasma-membrane lipid bilayer: ROS attacks membrane PUFAs, driving lipid peroxidation and generating cytotoxic aldehydes such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), which compromise membrane integrity and fluidity and impair motility/fertilization-related functions

Originally only described for the reduction of GSH-mixed disulfides, the monothiol reaction mechanism may also be functional for the reduction of certain protein disulfides, e.g., mammalian RNR and engineered GFP variants [36,37]

Moreover, various drugs and interventions, including natural compounds, enzymes from animal or plant sources [246,247,248,249,250,251,252], microbiota and derivatives [253,254,255], endogenous steroids [256, 257], and exercise [258], have been implicated in modulating the IGF pathway and potentially improving pathology and cognitive function in animal models of AD