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[63] explored the influence of the stapled strategy on the bioactivity and proteolytic stability of hymenochirin-1B and found that certain analogs have increased protease resistance relative to the liner peptide

This uncertainty creates a precautionary gap- both regulators and manufacturers may be cautious, delaying product approvals until more safety data are available

[DOI] [PubMed] [Google Scholar] 7.Rhim HC, et al

J Biol Chem 1997, 272:182188

Accordingly, the unique genomic map of SARS-CoV-2 virus and the extent of its mediated virushost proteinprotein interactions that trigger human metabolic reprogramming and dysregulation (HMRD) in favor of the virus life cycle, defines the ultimate severity and fate of COVID-19 23,24,25,26