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JXL: Conceptualization, Writing review & editing

Kanglexin attenuates spinal cord injury by modulating pyroptosis and polarization via the PKA/NF-B signaling pathway

Pore-forming toxins produced by various bacteria, including Staphylococcus aureus , Streptococcus pyogenes , Clostridium perfringens , and Aeromonas hydrophila , activate the IRE1-Xbp1 pathway in response to PFT-induced ER stress, serving as a defense mechanism [133]

Igarashi H, Takahashi T, Takahashi E, Tezuka N, Nakahara K, Takahashi K, Kurachi H

Upon hydrolysis, the resulting aglycones or secondary metabolites more readily penetrate the nucleus and mitochondria, where they modulate oxidative stress