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If the application is authorized, the manufacturer is directed to conduct certain studies to determine how the modified-risk authorization order impacts consumer perception, behavior and health, giving the FDA the ability to review whether the basis for its grant of the MRTP application was correct

3 Results 3.1 Fluoxetine pretreatment increases adolescent quinpirole-induced locomotion via 5-HT 1A receptors As shown in Figure 1 fluoxetine pretreatment of adolescents, but not adults, increased quinpirole-induced locomotor activity via a 5-HT 1A R mechanism

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