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Leombruni, M

It was reported that the ER stress inducer (thapsigargin or tunicamycin) or cisplatin alone was incapable to elicit the translocation of CRT from the lumen of the ER to the cell surface to induce CRT exposure and ICD [13]

A pH of 7.4 was used to simulate neutral physiological conditions, while a pH of 5.6 was selected to mimic the acidic environment of endosomes in tumor cells

Here we unveiled an essential role of E3 ligase SMAD ubiquitylation regulatory factor 1 (Smurf1)-mediated phosphoinositide-dependent protein kinase 1 (PDK1) neddylation in PI3KAkt signaling and tumorigenesis