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Neutrophils, platelets, and inflammatory pathways at the nexus of sickle cell disease pathophysiology

De Santi, C

doi: 10.1016/j.cell.2021.04.048 29

The clinical implications of these findings are substantial, and suggest that targeting GM through FMT and other microbiome-modulating therapies like prebiotics and probiotics may not only alleviate GI symptoms associated with PD but also enhance SCFAs, and anti-inflammatory cytokines (IL-6, IL-10) production, while decreasing pro-inflammatory cytokines and chemokines (MCP-1 and IL-8) (48)

When comparative data were available, these studies consistently reported similar mobilization yields and adverse events (AEs) between Sandoz biosimilar filgrastim and the reference filgrastim