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However it should be noted that the biological activities and therapeutic effects of polyphenols are also potentially mediated by their metabolites formed in the gut, liver, or gut microbiota, therefore demonstrating the complexity of polyphenols in this context [589,590]

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As an illustration, research shows that the amount of glutathione-specific -glutamylcyclotransferase 1 (CHAC1) is related to the viability of PCa cells and the levels of GSH [31]

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