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[DOI] [PubMed] [Google Scholar] 253.Harui A, Roth MD

Research findings point to the capacity of busulfan to induce cellular senescence in various cell types, including mesenchymal stem cells, fibroblasts, and the cell lines of human osteosarcoma cells U2OS and MG63 [65,66,67]

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As for CASP3, studies have shown a correlation between abnormal expression and BRCA patient prognosis, and an abnormal CASP3-mediated apoptosis pathway is a potential mechanism of chemoresistance in BRCA 40,41