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A large number of studies in vivo and animal investigations demonstrate that natural products such as quercetin, luteolin, resveratrol, and curcumin can effectively regulate multiple forms of PCD, including apoptosis, autophagy, ferroptosis, and pyroptosis, regulating key signaling pathways including PI3K/Akt, MAPK, NF-B, Nrf2, and GPX4, thereby inhibiting the development of EMs

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The active binding sites of the ligand should be accessible to the components of the mixture for easy binding, and the binding sites should not be deformed during the immobilization of the ligand to the solid support