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To solve the paradox that pre-existing high concentrations of ROS in the TME can conversely inhibit immunity, the most advanced strategy is to develop multifunctional nanovaccines that first clear, then activate. Such vaccines can first use their material properties to scavenge the inhibitory ROS in the TME, creating a favorable environment for immune cells, and then strongly activate DCs by releasing immune agonists, ultimately triggering a systemic anti-tumor immunity [265]

Abcam, ab133524) to tissue microarrays (TMA, two cores per case) of formalin fixed and paraffin embedded (FFPE) NSCLC and SCLC specimens

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APS is primarily absorbed through passive pathways in vivo , but its absorption efficiency is relatively low

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