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We studied two mouse models of 22q11.2DS using mass spectrometry, nuclear magnetic resonance spectroscopy, and transcriptomics

In contrast, we observed that the decreased levels of metabolites such as L-tryptophan and sphingosine 1-phosphate were negatively correlated with changes in the levels of TNF- and IL-17, but positively correlated with reduced levels of chemokines, such as MIP-1 and IL-8 ( Figure 6 )